
%0 Journal Article
%A Piggott, Matthew J. 
%A Wege, Dieter 
%T The Synthesis of Ventilone A
%J Australian Journal of Chemistry
%D 2000/12/22
%V 53
%N 9
%P 749-754
%K Anthranilic acid; benzyne; oxazole; furan; cycloaddition.
%R https://doi.org/10.1071/CH00057
%U https://www.publish.csiro.au/paper/CH00057 
%X 2-Amino-3,6-dimethoxy-4,5-methylenedioxybenzoic acid (12) was prepared from 1,4-dimethoxy-2,3-methylenedioxybenzene (8) via the isatin (11). The benzyne generated from (12) was intercepted with 3-acetyl-2-ethoxy-4-&#91;(4-methoxyphenoxy)methyl&#93;furan (4) to give the naphthol (27), which on treatment with cericammonium nitrate gave the dimethyl ether of ventilone A(29). Demethylation with boron tribromide then affordedventilone A (1). 
