
TY  - JOUR
A1  - Bugarcic, Zivadin D. 
A1  - Ilic, Dragoslav 
A1  - Djuran, Milos I. 
T1  - <emph type="2">Short Communication</emph>: Kinetic Study of the Interactions of Palladium(II) Complexes with Thiols in Acidic Aqueous Solution
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2001
VL  - 54
IS  - 4
SP  - 237
EP  - 240
KW  - 
UR  - https://doi.org/10.1071/CH01031 
N2  - The kinetics of complex formation between the monofunctional palladium(II) complexes &#91;Pd(dien)Cl&#93;+ and &#91;Pd(gly&#8211;met-S,N,N&acute;)Cl&#93;, where (dien) is diethylentriamine and (gly&#8211;met) is glycyl&#8211;L-methionine, and L-cysteine, DL-penicillamine and glutathione were studied in an aqueous 0.10 mol dm&#8211;3 perchloric acid medium by using variable-temperature stopped-flow spectrophotometry. Second-order rate constants, k2298, varied between 17.02 and 1.44103 M-1 s-1. Higher reactivity was observed for the &#91;Pd(dien)Cl&#93;+ complex, whereas glutathione was found to be the strongest nucleophile. The reactivity of the thiol nucleophile follows the sequence DL-penicillamine &#60; L-cysteine &#60; glutathione. However, the variation in size, bulk and solvation of the entering thiols reflects their properties as nucleophiles. Negative entropies of activation support a strong contribution from bond making in the transition state of the process. Manuscript received: 4 April 2001. Final version: 2 August 2001. 
ER  -

