
%0 Journal Article
%A Deady, Leslie W. 
%A Rodemann, Thomas 
%T Reduced Benzimidazo[2,1-<emph type="2">a</emph>]isoquinolines. Synthesis and Cytotoxicity Studies
%J Australian Journal of Chemistry
%D 2002/02/04
%V 54
%N 8
%P 529-534
%K 
%R https://doi.org/10.1071/CH01114
%U https://www.publish.csiro.au/paper/CH01114 
%X 6-Butyl-5,6-dihydrobenzimidazo&#91;2,1-a&#93;isoquinoline, 3,9- and 3,10-dimethoxy, and 3,9- and 3,10-dihydroxy analogues, and their 12-methyl quaternary salts were prepared by a multistep route. Cytotoxicities against 55 human cancer cell lines were measured in the National Cancer Institute screen. The quaternary salts of the dimethoxy compounds (15b/c) were clearly the most active overall, with a mean graph midpoint (MGM) value of 2 m. 
