
TY  - JOUR
A1  - Deady, Leslie W. 
A1  - Rodemann, Thomas 
T1  - Reduced Benzimidazo[2,1-<emph type="2">a</emph>]isoquinolines. Synthesis and Cytotoxicity Studies
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2002
VL  - 54
IS  - 8
SP  - 529
EP  - 534
KW  - 
UR  - https://doi.org/10.1071/CH01114 
N2  - 6-Butyl-5,6-dihydrobenzimidazo&#91;2,1-a&#93;isoquinoline, 3,9- and 3,10-dimethoxy, and 3,9- and 3,10-dihydroxy analogues, and their 12-methyl quaternary salts were prepared by a multistep route. Cytotoxicities against 55 human cancer cell lines were measured in the National Cancer Institute screen. The quaternary salts of the dimethoxy compounds (15b/c) were clearly the most active overall, with a mean graph midpoint (MGM) value of 2 m. 
ER  -

