
%0 Journal Article
%A Davis, Rohan A. 
%A Carroll, Anthony R. 
%A Quinn, Ronald J. 
%T The Synthesis of a Combinatorial Library Using a Tambjamine Natural Product Template
%J Australian Journal of Chemistry
%D 2001/12/10
%V 54
%N 6
%P 355-359
%K 
%R https://doi.org/10.1071/CH01123
%U https://www.publish.csiro.au/paper/CH01123 
%X The first demonstration of a parallel solution-phase synthesis using a tambjamine natural product template is reported. Isolation of the salts of tambjamines C (1), E (2) and F (3) from the Great Barrier Reef ascidian Sigillina signifera, followed by base hydrolysis, produced the known metabolite 4-methoxy-2-(1H-pyrrol-2&acute;-yl)-1H-pyrrole-5-carbaldehyde (4). This aldehyde was subsequently used in a one-step synthesis to generate an enamine library. A simple liquid&#8211;liquid partitioning scheme was employed for purification and provided 10 tambjamine analogues in high purity. 
