
TY  - JOUR
A1  - Davis, Rohan A. 
A1  - Carroll, Anthony R. 
A1  - Quinn, Ronald J. 
T1  - The Synthesis of a Combinatorial Library Using a Tambjamine Natural Product Template
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2001
VL  - 54
IS  - 6
SP  - 355
EP  - 359
KW  - 
UR  - https://doi.org/10.1071/CH01123 
N2  - The first demonstration of a parallel solution-phase synthesis using a tambjamine natural product template is reported. Isolation of the salts of tambjamines C (1), E (2) and F (3) from the Great Barrier Reef ascidian Sigillina signifera, followed by base hydrolysis, produced the known metabolite 4-methoxy-2-(1H-pyrrol-2&acute;-yl)-1H-pyrrole-5-carbaldehyde (4). This aldehyde was subsequently used in a one-step synthesis to generate an enamine library. A simple liquid&#8211;liquid partitioning scheme was employed for purification and provided 10 tambjamine analogues in high purity. 
ER  -

