
%0 Journal Article
%A Anastasiadis, Aphrodite 
%A Separovic, Frances 
%A White, Jonathan 
%T Synthesis of Deuterated Aminocaproyl Linkers
%J Australian Journal of Chemistry
%D 2002/04/26
%V 54
%N 12
%P 747-750
%K 
%R https://doi.org/10.1071/CH01179
%U https://www.publish.csiro.au/paper/CH01179 
%X Gramicidin A (gA) analogues with a biotin attached to the C-terminus by an aminocaproyl linker are used as ion channels in the AMBRI&reg; biosensor and are referred to as biotinylated gA. In order to examine the conformation and dynamics of the aminocaproyl linker by 2H solid-state nuclear magnetic resonance, the synthesis of deuterated aminocaproic acid is required. We report on the synthesis of (D10)-6-aminocaproic acid from commercially available perdeuterated cyclohexanol and its covalent attachment to the C-terminal group of gA to form gAXDXB. 
