
TY  - JOUR
A1  - Anastasiadis, Aphrodite 
A1  - Separovic, Frances 
A1  - White, Jonathan 
T1  - Synthesis of Deuterated Aminocaproyl Linkers
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2002
VL  - 54
IS  - 12
SP  - 747
EP  - 750
KW  - 
UR  - https://doi.org/10.1071/CH01179 
N2  - Gramicidin A (gA) analogues with a biotin attached to the C-terminus by an aminocaproyl linker are used as ion channels in the AMBRI&reg; biosensor and are referred to as biotinylated gA. In order to examine the conformation and dynamics of the aminocaproyl linker by 2H solid-state nuclear magnetic resonance, the synthesis of deuterated aminocaproic acid is required. We report on the synthesis of (D10)-6-aminocaproic acid from commercially available perdeuterated cyclohexanol and its covalent attachment to the C-terminal group of gA to form gAXDXB. 
ER  -

