
%0 Journal Article
%A Zheng, M. 
%A Endo, T. 
%A Zimmermann, W. 
%T Enzymatic Synthesis and Analysis of Large-Ring Cyclodextrins
%J Australian Journal of Chemistry
%D 2002/06/04
%V 55
%N 2
%P 39-48
%K 
%R https://doi.org/10.1071/CH01189
%U https://www.publish.csiro.au/paper/CH01189 
%X Large-ring cyclodextrins (LR-CD) are cyclic &#945;-1,4-glucans composed of nine to more than several hundred glucopyranose units. Cyclodextrins are able to form highly specific inclusion complexes with a wide range of guest molecules thereby modifying their physicochemical properties. Only in the past 10 years, LR-CD with a degree of polymerization between 9 and 32 have been isolated and characterized. The structures of these LR-CD show novel features distinct from those of the extensively studied &#945;- &#946;-, and &#947;-CD composed of six, seven, and eight glucopyranose units, respectively. Recent work on the enzymatic synthesis of LR-CD has confirmed the ability of different 4-&#945;-glucanotransferases to form large cyclic &#945;-1,4-glucans from amylose and amylopectin, depending on the specificity of the enzyme used and on the substrate and reaction conditions chosen. The potential of LR-CD for specific host-guest interactions and corresponding applications has been demonstrated. 
