
%0 Journal Article
%A Battle, Andrew R. 
%A Deacon, Glen B. 
%A Dolman, Rachael C. 
%A Hambley, Trevor W. 
%T Electrochemistry, Protein Binding and Crystal Structures of Platinum(II) and Platinum(IV) Carboxylato Complexes
%J Australian Journal of Chemistry
%D 2002/12/23
%V 55
%N 11
%P 699-704
%K 
%R https://doi.org/10.1071/CH02086
%U https://www.publish.csiro.au/paper/CH02086 
%X The crystal structures of the platinum(II) complexes [Pt(ox)(en)] (ox = oxalato, en = ethane-1,2-diamine) and [Pt(ethmal)(en)] (ethmal = ethylmalonato), and of their platinum(IV) analogues, trans-[Pt(OH)2(ox)(en)].H2O and trans-[Pt(ethmal)(OH)2(en)], have been determined. All crystallize in the monoclinic space group P21/c, with the exception of trans-[PtIV(OH)2(ox)(en)].H2O which crystallizes in C2/c. The ethylmalonato ligand in [PtII(ethmal)(en)] adopts a pseudo-boat conformation. Changes in the fold angles of the boat occur on oxidation and introduction of the trans hydroxo ligands. The cathodic forward half-wave potentials of the platinum(iv) complexes (including trans-[Pt(mal)(OH)2(en)], mal = malonato) are reported and reveal that these complexes are more difficult to reduce than analogous complexes with equatorial chloro ligands. The binding of trans-[Pt(OH)2(ox)(en)].H2O and trans-[Pt(mal)(OH)2(en)] to mouse albumin was investigated with no binding observed after 6 h and a very small amount observed for the latter complex after 24 h. 
