
TY  - JOUR
A1  - Rosamilia, A. E. 
A1  - Mayes, P. A. 
A1  - Papadopoulos, R. 
A1  - Campi, E. M. 
A1  - Jackson, W. R. 
A1  - Rash, L. 
A1  - Jarrott, B. 
T1  - Synthesis of Some Nefopam Analogues as Potential Analgesics
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2002
VL  - 55
IS  - 9
SP  - 577
EP  - 585
KW  - 
UR  - https://doi.org/10.1071/CH02097 
N2  - Some derivatives of the non-narcotic analgesic nefopam containing amidine and guanidine substituents have been prepared and their analgesic activity assessed by their ability to block the uptake of noradrenaline. The compounds have been shown to inhibit noradrenaline uptake but they also display possible &#945;1 antagonist activity at higher concentration. An ester derivative was also active and was more selective as it did not exhibit &#945;1 adrenoreceptor antagonism. 
ER  -

