
TY  - JOUR
A1  - Hambley, Trevor W. 
A1  - Katsifis, Andrew 
A1  - Knott, Robert B. 
A1  - Mattner, Filomena 
A1  - Dikic, Branko 
T1  - The Structures of Imidazenil and Iodoimidazenil
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2002
VL  - 55
IS  - 11
SP  - 737
EP  - 739
KW  - 
UR  - https://doi.org/10.1071/CH02123 
N2  - The iodinated analogue of imidazobenzodiazepine, imidazenil (1), has been prepared with the aim of radiolabelling it with iodine-123 and including it in a study to determine the role of benzodiazepine receptors in neurodegenerative diseases using single photon emission computer tomography (SPECT) imaging. A comparison of the bromo- and iodo-derivatives, as well as the conformational changes resulting from bromine&#8211;iodine substitution are described, and it is concluded that the substitution has no clear effect on the geometry. Crystal structures of (1) and iodoimidazenil (2) have been determined by X-ray diffraction methods and refined to R values of 0.059 (3817 F) and 0.048 (1318 F), respectively. The crystals of imidazenil are triclinic, space group P1&#8211;,a 12.537(4), b 18.211(6), c 7.852(2) &#197;, &#945; 91.07(2), &#946; 106.26(2), &#947; 77.86(2)°, Z 4, and those of iodoimidazenil are monoclinic, space group P21/a, a 12.185(2), b 7.558(2), c 18.287(2) &#197;, &#946; 95.23(1)°, Z 4. 
ER  -

