
TY  - JOUR
A1  - Macdonald, James M. 
A1  - Stick, Robert V. 
A1  - Tilbrook, D. Matthew G. 
A1  - Withers, Stephen G. 
T1  - Synthesis with Glycosynthases: Cello-Oligomers of Isofagomine and a Tetrahydrooxazine as Cellulase Inhibitors
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2003
VL  - 55
IS  - 12
SP  - 747
EP  - 752
KW  - 
UR  - https://doi.org/10.1071/CH02165 
N2  - Isofagomine and a carbohydrate-like tetrahydrooxazine, as their N-benzyloxycarbonyl derivatives, have been subjected to a glycosynthase in the presence of &#945;-D-glucopyranosyl fluoride as a glucosyl donor. In each case, after protecting group removal, a mixture of 1,4-&#946;-linked di-, tri-, and tetra-&#39;saccharides&#39; was obtained. These novel oligosaccharide derivatives were tested as inhibitors of the endo-glycanase Cex from Cellulomonasfimi. Affinities increased progressively as additional D-glucosyl residues were incorporated, which is consistent with the known substrate specificity of this enzyme. 
ER  -

