
TY  - JOUR
A1  - Giannikopoulos, Georgina 
A1  - Teo, Chih-Lynne 
A1  - Hall, Matthew D. 
A1  - Fenton, Ronald R. 
A1  - Hambley, Trevor W. 
T1  - The Synthesis and in Vitro Cytotoxicity of Two <emph type="2">trans</emph>-Platinum Complexes of Heterocyclic Amines
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2003
VL  - 56
IS  - 7
SP  - 685
EP  - 689
KW  - 
UR  - https://doi.org/10.1071/CH03021 
N2  - The syntheses and crystal structures of the platinum(II) complexes trans-[PtCl2(DMSO)(C4H9NO)] and trans-[PtCl2(DMSO)(dmdze)] are described and the mechanisms leading to their formation are discussed. The complex trans-[PtCl2(DMSO)(C4H9NO)] crystallizes in the triclinic space group P1, a 8.1432(8), b 8.5224(8), c 9.0801(9) &#197;, &#945; 111.780(1), &#946; 91.074(2), &#947; 98.349(2)&#176;, Z 2, and its structure was refined to an R value of 0.019 on 2470 F. The cytotoxicity of this complex was determined and was found to be lower than that of cisplatin. The complex trans-[PtCl2(DMSO)(dmdze)] crystallizes in the monoclinic space group C2/c, a 23.498(5), b 8.048(2), c 17.859(6) &#197;, &#946; 120.88(2), Z 8, and its structure was refined to an R value of 0.034 on 2712 F. 
ER  -

