
%0 Journal Article
%A Fenton, Ronald R. 
%A Lindoy, Leonard F. 
%A Price, Jason R. 
%A Skelton, Brian W. 
%A White, Allan H. 
%T New Macrocyclic Ligands. XVI. Synthesis of a Series of <emph type="2">N</emph>-Benzylated Macrocycles Incorporating N<emph type="8">4</emph>O<emph type="2">2</emph>-Donor Set
%J Australian Journal of Chemistry
%D 2003/10/29
%V 56
%N 11
%P 1141-1145
%K 
%R https://doi.org/10.1071/CH03079
%U https://www.publish.csiro.au/paper/CH03079 
%X The synthesis of five 20-membered, N-benzylated macrocyclic ligands incorporating N4O2-donor sets and from one to three benzyl substituents for use in metal-ion recognition studies is described. The new derivatives were obtained by both benzylation of the pre-formed parent macrocycle using benzyl chloride in acetonitrile in the presence of base or, in one case, by performing macrocyclic ring closure using the appropriate N-benzylated triamine precursor by means of a bis-Schiff base condensation with the corresponding dialdehyde, followed by in situ reduction of the diamine linkages so formed. The single crystal X-ray structure of the symmetrically substituted, di-N-benzylated derivative is reported. 
