
TY  - JOUR
A1  - Fenton, Ronald R. 
A1  - Lindoy, Leonard F. 
A1  - Price, Jason R. 
A1  - Skelton, Brian W. 
A1  - White, Allan H. 
T1  - New Macrocyclic Ligands. XVI. Synthesis of a Series of <emph type="2">N</emph>-Benzylated Macrocycles Incorporating N<emph type="8">4</emph>O<emph type="2">2</emph>-Donor Set
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2003
VL  - 56
IS  - 11
SP  - 1141
EP  - 1145
KW  - 
UR  - https://doi.org/10.1071/CH03079 
N2  - The synthesis of five 20-membered, N-benzylated macrocyclic ligands incorporating N4O2-donor sets and from one to three benzyl substituents for use in metal-ion recognition studies is described. The new derivatives were obtained by both benzylation of the pre-formed parent macrocycle using benzyl chloride in acetonitrile in the presence of base or, in one case, by performing macrocyclic ring closure using the appropriate N-benzylated triamine precursor by means of a bis-Schiff base condensation with the corresponding dialdehyde, followed by in situ reduction of the diamine linkages so formed. The single crystal X-ray structure of the symmetrically substituted, di-N-benzylated derivative is reported. 
ER  -

