
%0 Journal Article
%A Bodkin, Jennifer A. 
%A Humphries, Edward J. 
%A McLeod, Malcolm D. 
%T The Total Synthesis of (&#8211;)-Tetrahydrolipstatin
%J Australian Journal of Chemistry
%D 2003/07/18
%V 56
%N 8
%P 795-803
%K 
%R https://doi.org/10.1071/CH03121
%U https://www.publish.csiro.au/paper/CH03121 
%X Careful control during the bromolactonization of &#946;,&#947;;-unsaturated acid (4) was required to regioselectively afford the trans-&#946;-lactone (3) as the major diastereomer. Radical debromination of (3) followed by a three-step sequence of reactions afforded the lipase inhibitor (&#8211;)-tetrahydrolipstatin (1). 
