
TY  - JOUR
A1  - Tuttle, C. T. Tell 
A1  - Seabrook, Shane A. 
A1  - Wise, Lauren E. 
A1  - Katsifis, Andrew 
A1  - Knott, Robert B. 
A1  - Yates, Brian F. 
T1  - Molecular Modelling and Design of Radiolabelled Complexes for Melanoma Diagnosis
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2004
VL  - 57
IS  - 1
SP  - 87
EP  - 96
KW  - isotopic labelling &#8212; molecular modelling &#8212; pharmeceutical chemistry &#8212; QSAR
UR  - https://doi.org/10.1071/CH03165 
N2  - Molecular modelling has been used to analyze a database of compounds with known binding affinities for the integrin receptors &#945;V&#946;3 and &#945;IIb&#946;3. We describe how a variety of novel radiolabelled compounds (specifically 131I labelled) were designed and how the binding affinity of these compounds to the two integrin receptors was predicted. The selectivity for the &#945;V&#946;3 receptor has also been predicted and a summary of some of the best candidates for positron emission tomography (PET) imaging is provided. This work will have significant implications for the development of diagnostic (and possibly therapeutic) drugs for melanomas. 
ER  -

