
%0 Journal Article
%A Loughlin, Wendy A. 
%A Murphy, Michelle E. 
%A Elson, Kathryn E. 
%A Henderson, Luke C. 
%T Synthesis of a Novel Pyrrole Oxazole Analogue of the Insecticide Pirate
%J Australian Journal of Chemistry
%D 2004/03/01
%V 57
%N 3
%P 227-232
%K insecticides &#8212; synthesis (org.) &#8212; combinatorial chemistry &#8212; pyrrole &#8212; QSAR
%R https://doi.org/10.1071/CH03184
%U https://www.publish.csiro.au/paper/CH03184 
%X The pyrrole oxazole 4 is a novel analogue of the broad-spectrum insecticide and miticide pirate 2. The expedient synthesis of pyrrole oxazole 4 in six steps from pyrrole is reported using a synthetic route that could have potential for the solution-phase combinatorial synthesis of analogues. Preliminary biological evaluation of the protected pyrrole oxazole 4 (LD50 1.13 &#956;g mL&#8211;1) and the deprotected pyrrole oxazole 5 (LD50 1.06 &#956;g mL&#8211;1) for potential cytotoxicity was carried out. 
