
%0 Journal Article
%A McDonough, Matthew J. 
%A Stick, Robert V. 
%A Tilbrook, D. Matthew G. 
%A Watts, Andrew G. 
%T An Investigation into the Synthesis of Some Molecules Related to Methyl Acarviosin
%J Australian Journal of Chemistry
%D 2004/03/01
%V 57
%N 3
%P 233-241
%K glycosides &#8212; synthesis (org.) &#8212; glycosylation &#8212; glucosidic linkages &#8212; methyl acarviosin
%R https://doi.org/10.1071/CH03185
%U https://www.publish.csiro.au/paper/CH03185 
%X Methyl acarviosin is an impressive inhibitor of some glycoside hydrolases that process substrates containing &#945;-D-glucosidic linkages. In an attempt to provide putative inhibitors for enzymes that process &#946;-D-glucosidic linkages, we report an improved synthesis of a hydroxylated &#8216;methyl &#946;-acarviosin&#8217; and our efforts towards various deoxygenated versions of methyl &#946;-acarviosin. As well, the synthesis of a 1,3-linked variant of methyl &#946;-acarviosin is reported, together with an unsuccessful &#8216;tether&#8217; approach to construct the crucial nitrogen linkage in the acarviosins. 
