
TY  - JOUR
A1  - McDonough, Matthew J. 
A1  - Stick, Robert V. 
A1  - Tilbrook, D. Matthew G. 
A1  - Watts, Andrew G. 
T1  - An Investigation into the Synthesis of Some Molecules Related to Methyl Acarviosin
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2004
VL  - 57
IS  - 3
SP  - 233
EP  - 241
KW  - glycosides &#8212; synthesis (org.) &#8212; glycosylation &#8212; glucosidic linkages &#8212; methyl acarviosin
UR  - https://doi.org/10.1071/CH03185 
N2  - Methyl acarviosin is an impressive inhibitor of some glycoside hydrolases that process substrates containing &#945;-D-glucosidic linkages. In an attempt to provide putative inhibitors for enzymes that process &#946;-D-glucosidic linkages, we report an improved synthesis of a hydroxylated &#8216;methyl &#946;-acarviosin&#8217; and our efforts towards various deoxygenated versions of methyl &#946;-acarviosin. As well, the synthesis of a 1,3-linked variant of methyl &#946;-acarviosin is reported, together with an unsuccessful &#8216;tether&#8217; approach to construct the crucial nitrogen linkage in the acarviosins. 
ER  -

