
%0 Journal Article
%A Fong, Mei 
%A Janowski, Wit K. 
%A Prager, Rolf H. 
%A Taylor, Max R. 
%T A Convenient Synthesis of 2-Substituted Thiazole-5-carboxylates
%J Australian Journal of Chemistry
%D 2004/05/21
%V 57
%N 6
%P 599-604
%K 
%R https://doi.org/10.1071/CH03252
%U https://www.publish.csiro.au/paper/CH03252 
%X The photolysis of ethyl 5-oxo-2-phenyl-2,5-dihydroisoxazole-4-carboxylate in acetonitrile containing 0.5% tri- fluoroacetic acid in the presence of thioamides gives moderate (40&#8211;60%) yields of thiazole-5-carboxylate esters. In the absence of trifluoroacetic acid, the intermediate vinyl thioesters can be isolated. That addition of the thioamide to the first formed carbene was, through sulfur, confirmed by X-ray crystal structures of 2-methylthiazole-5-carboxylic acid and a byproduct. 
