
%0 Journal Article
%A Sheldon, Roger A. 
%A Rantwijk, Fred van 
%T Biocatalysis for Sustainable Organic Synthesis
%J Australian Journal of Chemistry
%D 2004/04/01
%V 57
%N 4
%P 281-289
%K antibiotics&#8212;biotechnology&#8212;CLEAs&#8212;enzymes&#8212;industrial chemistry
%R https://doi.org/10.1071/CH03291
%U https://www.publish.csiro.au/paper/CH03291 
%X Biocatalysis offers mild reaction conditions, an environmentally attractive catalyst&#8211;solvent system, high activities, and chemo-, regio-, and stereoselectivities, while the use of enzymes generally circumvents the need for functional group activation and avoids protection/deprotection steps required in traditional organic syntheses. This review, using &#946;-lactam antibiotics as an example, discusses recent advances in biocatalysis research towards the goal of &#8216;green&#8217; methodologies for the manufacture of (fine) chemicals and the emulation of a cell&#39;s enzymatic cascade processes. 
