
%0 Journal Article
%A Takagi, Ryukichi 
%A Tsuyumine, Shinjiro 
%A Nishitani, Hiroko 
%A Miyanaga, Wataru 
%A Ohkata, Katsuo 
%T Stereoselective Synthesis of the Hydrophobic Side Chain of Scyphostatin
%J Australian Journal of Chemistry
%D 2004/05/06
%V 57
%N 5
%P 439-447
%K 
%R https://doi.org/10.1071/CH03298
%U https://www.publish.csiro.au/paper/CH03298 
%X The hydrophobic side chain of scyphostatin was synthesized by a convergent synthetic pathway. The key reactions were the enzymatic asymmetric acetylation of a meso-diol, construction of the C12&#8242;&#8211;C13&#8242; trisubstituted E-olefin moiety by Negishi coupling, and construction of the (2&#8242;E,4&#8242;E ,E,6&#8242;E)-triene moiety by Horner&#8211;Wadsworth&#8211;Emmons olefination. 
