
%0 Journal Article
%A Tietze, Lutz F. 
%A Lücke, Lars P. 
%A Major, Felix 
%A Müller, Peter 
%T Efficient Synthesis of an Enantiopure Thiasteroid by a Double Heck Reaction
%J Australian Journal of Chemistry
%D 2004/07/07
%V 57
%N 7
%P 635-640
%K 
%R https://doi.org/10.1071/CH04034
%U https://www.publish.csiro.au/paper/CH04034 
%X The thiaestrane 7 was synthesized by two sequential Heck reactions starting from the thiophene derivatives 8a&#8211;8c, which contain a (Z)-halogenovinyl group, and the enantiopure hydrindene 2a. The first intermolecular Pd-catalyzed reaction leads to 11a and 11b in a highly regio- and diastereoselective manner. A subsequent intramolecular Heck reaction catalyzed by the palladacycle 4 then gave the thiasteroid 7 with an unusual cis-junction of the rings B and C. 
