
%0 Journal Article
%A Downes, AM 
%T Isotope Effect in the Reaction of <sup>14</sup>C-Formaldehyde with Dimedone
%J Australian Journal of Chemistry
%D 1952/09/01
%V 5
%N 3
%P 521-529
%K 
%R https://doi.org/10.1071/CH9520521
%U https://www.publish.csiro.au/paper/CH9520521 
%X Formulae for the specific activity of a labelled product at any stage in a reaction which involves an &quot; isotope effect &quot; are discussed. The investigation of isotope effect by isolating a labelled product in consecutive fractions is illustrated by the reaction of 14C-formaldehyde with dimedone. In this reaction the 14C-formaldehyde reacts 0.927± 0.005 times as rapidly as the unlabelled compound at room temperature.   Care must be taken when using dimedone as a derivative for the accurate assay of isotopic formaldehyde if errors due to isotope effect are to be avoided. 
