
%0 Journal Article
%A Hancox, NC 
%T The reaction between acetone and ammonia. III. Reduced pyridine, deriviaties
%J Australian Journal of Chemistry
%D 1953/06/01
%V 6
%N 2
%P 143-151
%K 
%R https://doi.org/10.1071/CH9530143
%U https://www.publish.csiro.au/paper/CH9530143 
%X The preparation of 2,2,4,6-tetramethyldihydropyridine by the reaction of acetone and ammonia at temperatures of 100-180 °C. has been studied; using an alkaline catalyst at 120 °C. for 3 hr, a yield of over 60 per cent. can be obtained. This dihydro-pyridine is identical with the product obtained by Matter (1948) in the pyrolysis of 2,2,4,4,6-pentamethyltetrahydropyrimidine Possible mechanisms for its formation are discussed. Catalytic hydrogenation over Raney nickel leads to tetramethyl-piperidine, while with palladium a partial reduction product, formulated as 2,2,4,6-tetramethyl-2,3,4,5-tetrahydropyridine is obtained ; the chemistry of these reduction products has been examined. 
