
%0 Journal Article
%A Leach, SJ 
%A Baxendale, JH 
%A Evans, MG 
%T The kinetics of Oxidation of N-Methylacridan:  A Model for Coenzyme 1
%J Australian Journal of Chemistry
%D 1953/12/01
%V 6
%N 4
%P 409-421
%K 
%R https://doi.org/10.1071/CH9530409
%U https://www.publish.csiro.au/paper/CH9530409 
%X The rates of oxidation of N-methylacridan by 2,6-dichlorophenolindophenol have been measured between pH 2.74 and 6.91 at 20 to 22 °C in the presence of 8 to 22 per cent. ethanol. The reaction was of the second order and was found to proceed by ' two simultaneous mechanisms, both involving the conjugate acid of N-methylacridan. The oxidation of this cation by the indophenol anion proceeded at a rate which was 19 times greater than the oxidation by the uncharged indophenol molecule. It is shown that oxidation probably occurs by hydrogen atom transfer rather than electron transfer. A similar mechanism for the oxidation of dihydro-coenzyme I would account for its slow reactivity towards molecular oxygen and the biological necessity for mediating systems involving both hydrogen atoms and electrons. 
