
%0 Journal Article
%A Cymerman-Craig, J 
%A harrisson, RJ 
%T Synthetic Antispasmodics. I. Some 1,1-Diaryl-3-(4'-methyl-1'-piperazino)-1-propenes
%J Australian Journal of Chemistry
%D 1955/09/01
%V 8
%N 3
%P 378-384
%K 
%R https://doi.org/10.1071/CH9550378
%U https://www.publish.csiro.au/paper/CH9550378 
%X The Mannich bases obtained by reaction of 1-methylpiperazine and formaldehyde with acetophenone and 2-acetylthiophen respectively have been condensed with phenyl- and &#945;-thienylmagnesium bromide, giving the 1,1-diphenyl, 1,1-di-&#945;-thienyl, and 1-phenyl-1-&#945;-thienyl-3-(4'-methyl-1'-piperazino)propan-1-ols. These have been dehydrated to the corresponding 1-propenes. Both the propanols and the propenes exhibit antispasmodic activity. 
