
TY  - JOUR
A1  - Badger, GM 
A1  - Ennis, BC 
A1  - Matthews, WE 
T1  - Studies on the Doebner-Miller, Skraup, and Related Reactions. II. Preparation and Cyclization of 4-(2'-Nitroanilino)-3-methylbutan-2-one
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1963
VL  - 16
IS  - 5
SP  - 828
EP  - 832
KW  - 
UR  - https://doi.org/10.1071/CH9630828 
N2  - The intermediate adduct (e.g. III) formed in Skraup and Doebner-Miller reactions has the nature of a Mannich base. It has now been prepared from o-nitroaniline, formaldehyde, and methyl ethyl ketone by the Mannich reaction. It has been cyclized to 3,4-dimethyl-8-nitroquinoline under acidic oxidizing conditions; but it is not cyclized by neutral oxidants, nor by non-oxidizing acids or Lewis acids. 
ER  -

