
%0 Journal Article
%A Brown, DJ 
%A Lyall, JM 
%T Pyrimidine reactions. VI. The amination of chloropyrimidines with n-alkylamines
%J Australian Journal of Chemistry
%D 1964/07/01
%V 17
%N 7
%P 794-802
%K 
%R https://doi.org/10.1071/CH9640794
%U https://www.publish.csiro.au/paper/CH9640794 
%X The aminations of 2-chloro-4,6-dimethylpyrimidine and 4-chloro-2,6-dimethyl- pyrimidine by a series of n-alkylamines (3 moles) have been followed titrimetrically. Between 3° and 70° the rates of these apparently first-order reactions approximately double for each 10&quot; rise. A simple experimental method for predicting optimum conditions of temperature and time for such aminations has been developed. Addition of cuprous chloride has little effect on rates. Fifteen new n-alkylaminopyrimidines have been prepared. 
