
TY  - JOUR
A1  - Pinhey, JT 
A1  - Sternhell, S 
T1  - Structure of &#945;-hydroxysantonin and some aspects of the stereochemistry of related eudesmanolides and guaianolides
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1965
VL  - 18
IS  - 4
SP  - 543
EP  - 557
KW  - 
UR  - https://doi.org/10.1071/CH9650543 
N2  - Chemical and spectroscopic evidence shows that the principal metabolite of a-santonin isolated from the urine of dog, &#945;-hydroxysantonin, has structure (Ic; R = H, R' = OH).   P.m.r. evidence shows that artemisin has the same configuration at C6, C7, and C11 as &#945;-santonin and that 6-epiartemisin has the same configuration at C6, C7, and C11 as 6-epi-&#945;-santonin. &#946;-Santonin is the C11 epimer of a-santonin and the configuration at C6 and C7 in 1-desmotroposantonin is analogous to that in 6-epi-a-santonin. The p.m.r. spectra of &#968;-santonin, lumisantonin, isophoto-&#945;-santonic lactone, and 6-epi-isophoto-&#945;-santonic lactone are discussed. 
ER  -

