
%0 Journal Article
%A Brown, DJ 
%A Lyall, JM 
%T Pyrimidine reactions. IX. The amination of chloropyrimidines with branched alkylamines and Di-n-alkylamines
%J Australian Journal of Chemistry
%D 1965/05/01
%V 18
%N 5
%P 741-745
%K 
%R https://doi.org/10.1071/CH9650741
%U https://www.publish.csiro.au/paper/CH9650741 
%X The reactions of 2-chloro-4,6-dimethylpyrimidine and 4-chloro-2,6-dimethylpyrimidine with some branched-alkyl- and dialkyl-amines have been followed from 30° to 70° in the absence of solvent. At comparable temperatures, alkylamines with &#946;- or &#947;-branching approximated in reactivity to n-alkylamines, whereas those with &#945;-branching and the di-n-alkylamines had only about 5% of the above reactivity; t-butylamine with two a-branches had but 0.1% of the reactivity of n-butylamine. Optimum conditions of time and temperature, calculated from these measurements, have been used to prepare 16 new alkylaminopyrimidines in good yield. 
