
TY  - JOUR
A1  - Brown, DJ 
A1  - Lyall, JM 
T1  - Pyrimidine reactions. IX. The amination of chloropyrimidines with branched alkylamines and Di-n-alkylamines
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1965
VL  - 18
IS  - 5
SP  - 741
EP  - 745
KW  - 
UR  - https://doi.org/10.1071/CH9650741 
N2  - The reactions of 2-chloro-4,6-dimethylpyrimidine and 4-chloro-2,6-dimethylpyrimidine with some branched-alkyl- and dialkyl-amines have been followed from 30° to 70° in the absence of solvent. At comparable temperatures, alkylamines with &#946;- or &#947;-branching approximated in reactivity to n-alkylamines, whereas those with &#945;-branching and the di-n-alkylamines had only about 5% of the above reactivity; t-butylamine with two a-branches had but 0.1% of the reactivity of n-butylamine. Optimum conditions of time and temperature, calculated from these measurements, have been used to prepare 16 new alkylaminopyrimidines in good yield. 
ER  -

