
%0 Journal Article
%A Stewart, FHC 
%T Depsipeptide synthesis by accelerated active ester coupling
%J Australian Journal of Chemistry
%D 1968/06/01
%V 21
%N 6
%P 1639-1649
%K 
%R https://doi.org/10.1071/CH9681639
%U https://www.publish.csiro.au/paper/CH9681639 
%X Protected amino acid active esters react with &#945;-hydroxy acid esters in the presence of several equivalents of imidazole to form aminoaoyl hydroxy acid derivatives in high yield. p-Nitrophenyl, 8-quinolyl, and cyanomethyl esters have been employed as activated carboxyl components in the reaction. Several depsipeptide derivatives were synthesized using the accelerated active ester coupling procedure. Pentamethylbenzyl was used extensively as a carboxyl-protecting group in this work. 
