
%0 Journal Article
%A Bolton, PD 
%A Jackson, GL 
%T Hydrolysis of amides. III. Dilute acid hydrolysis of amides of the type R-CH<sub>2</sub>-CONH<sub>2</sub>
%J Australian Journal of Chemistry
%D 1969/03/01
%V 22
%N 3
%P 527-532
%K 
%R https://doi.org/10.1071/CH9690527
%U https://www.publish.csiro.au/paper/CH9690527 
%X Rate constants over a range of temperature, enthalpies of activation, and entropies of activation are reported for the dilute acid hydrolysis of n-valeramide, isovaleramide, 3,3-dimethylbutanamide, phenylacetamide, cyclohexylacetamide, methoxyacetamide, bromoacetamide, and chloroacetamide.     The rate constants of the first six amides together with those of two other alkyl-substituted acetamides taken from a previous paper are almost perfectly correlated by the Taft linear steric energy relationship. The enthalpies of activation, also, show a linear dependence on the steric parameter, Es. The results obtained for the halogeno amides indicate that the acid hydrolysis of amides may show a slight sensitivity to polar effects. 
