
%0 Journal Article
%A Birch, AJ 
%A Gager, F 
%A Mo, L 
%A Pelter, A 
%A Wright, JJ 
%T Studies in relation to biosynthesis. XLI. Canescin
%J Australian Journal of Chemistry
%D 1969/11/01
%V 22
%N 11
%P 2429-2436
%K 
%R https://doi.org/10.1071/CH9692429
%U https://www.publish.csiro.au/paper/CH9692429 
%X The biosynthesis of canescin (I) has been investigated. The isocoumarin portion is derived from a polyketide chain. One carbon atom of the &#947;- lactone ring and the carbon atom of the methoxyl group originate from methionine whilst the other three carbon atoms of the &#947;-lactone have a symmetrical C4-acid of the citric acid cycle as their precursor. This metabolite is most unusual in that an oxygenated methionine-derived carbon atom provides the growing point of a new carbon chain. A possible mechanism for the attachment of the lactone is suggested. 
