
TY  - JOUR
A1  - McTigue, PT 
A1  - Renowden, PV 
T1  - Kinetic medium effects. IV. Hydrolysis of trimethyl phosphate in mixed solvents
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1970
VL  - 23
IS  - 2
SP  - 297
EP  - 306
KW  - 
UR  - https://doi.org/10.1071/CH9700297 
N2  - The rate of hydrolysis of trimethyl phosphate (tmp) has been measured at 90.5º as a function of solvent composition in water-dimethyl sulphoxide and water-ethylene glycol mixtures. The rate constant of the &quot;spontaneous&quot; hydrolysis decreases with decreasing water content; an acid-catalysed reaction, whose rate constant increases with decreasing water content, becomes dominant at low water concentrations. Solvent isotope effects in D2O have been measured for both the spontaneous and acid-catalysed reactions, and are close to unity in each case. Salt effects have also been studied In aqueous sodium nitrate and perchlorate solutions, and are found to be small. Reaction mechanisms are discussed in the light of the results obtained. 
ER  -

