
TY  - JOUR
A1  - Bolton, PD 
A1  - Jackson, GI 
T1  - Hydrolysis of amides. V. Alkaline hydrolysis of alkyl-substituted amides
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1971
VL  - 24
IS  - 5
SP  - 969
EP  - 974
KW  - 
UR  - https://doi.org/10.1071/CH9710969 
N2  - Enthalpies and entropies of activation have been derived from rate constants measured over a range of temperature for the alkaline hydrolysis of acetamide, propionamide, n-butyramide, n-valeramide, isovaleramide, phenylacetamide, cyclohexylacetamide, methoxyacetamide, cyclohexanecarboxamide, cyclopentane carboxamide, &#945;-methylbutyramide, isobutyramide, and trimethylacetamide.     These results are discussed in terms of their correlation by Taft- type equations which have been extended to incorporate a factor based upon the ?&#945;-hydrogen bond? concept of hyperconjugative stabilization. The rate constants of these 13 amides under these conditions appear to be governed by a combination of polar, steric, and hyperconjugative factors. 
ER  -

