
%0 Journal Article
%A Stewart, FHC 
%T Use of N-2-cyanoethylglycine derivatives in the synthesis of peptides of N-2-carboxamidoethylglycine, an isomer of glutamine
%J Australian Journal of Chemistry
%D 1971/06/01
%V 24
%N 6
%P 1267-1275
%K 
%R https://doi.org/10.1071/CH9711267
%U https://www.publish.csiro.au/paper/CH9711267 
%X Derivatives of N-2-cyanoethylglycine have been employed as coupling components in the synthesis of protected peptides. The nitrile group in N-2-cyano-ethylglycine is readily hydrated by hydrogen bromide treatment with formation of N-2-carboxamidoethylglycine, which is an isomer of glutamine. This reaction, conducted on cyanoethyl intermediates with simultaneous cleavage of appropriate acid-labile protecting groups, was utilized to prepare several free peptides containing N-2-carboxamidoethylglycine residues. 
