
%0 Journal Article
%A Frahn, JL 
%A Illman, RJ 
%T Synthesis of 6-Methoxy-2-methyl-1,2,3,4-tetrahydro-&#946;-carboline
%J Australian Journal of Chemistry
%D 1974/06/01
%V 27
%N 6
%P 1367-1369
%K 
%R https://doi.org/10.1071/CH9741367
%U https://www.publish.csiro.au/paper/CH9741367 
%X A convenient, larger-scale preparation of 6-methoxy-2-methyl-l,2,3,4-tetrahydro-&#946;-carboline, an alkaloid occurring in the pasture grass, Phalavis tuberosa L., is described. DL-5-Methoxytryptophan is condensed with formaldehyde and the product, DL-6-methoxy-1,2,3,4-tetrahydro-&#946;-carboline-3-carboxylic acid, treated with dichromate to form 6-methoxy-&#946;-carboline. The methiodide of this base is reduced with borohydride to the required alkaloid in c.60% overall yield. 
