
%0 Journal Article
%A Collins, DJ 
%A Mollard, S 
%A Rose, N 
%A Swan, JM 
%T Organophosphorus compounds. XVI. 2-(N-Dialkylamino)alkyldiphenylphosphines, phosphine oxides and sulphides as analogues of methadone
%J Australian Journal of Chemistry
%D 1974/11/01
%V 27
%N 11
%P 2365-2372
%K 
%R https://doi.org/10.1071/CH9742365
%U https://www.publish.csiro.au/paper/CH9742365 
%X A series of 2-(N-dialkylamino)ethyldiphenylphosphine oxides and sulphides was prepared by the addition of a secondary amine to diphenylvinylphosphine oxide, or the phosphine sulphide, respectively. Similarly, a series of 2-(N-dialkylamino)propyldiphenylphosphine oxides was prepared from diphenylprop-1-enylphosphine oxide, or from diphenylprop-2-enylphosphine oxide which isomerized under the reaction conditions. Reduction of the 2-(N-dialkylamino)propyldiphenylphosphine oxides with trichlorosilane, and oxidation of the phosphines with sulphur, afforded the corresponding phosphine sulphides.     None of the compounds showed significant analgesic activity. 
