
TY  - JOUR
A1  - Prager, RH 
A1  - Reece, PA 
T1  - On the alkylation of &#945;-bromo ketones by trialkylboranes
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1975
VL  - 28
IS  - 8
SP  - 1775
EP  - 1783
KW  - 
UR  - https://doi.org/10.1071/CH9751775 
N2  - The reaction of 2-halocycloalkanones with organoboranes in the presence of base has been studied. The transfer of an alkyl group from boron to carbon is the rate-limiting step, and the nature of the intermediate is discussed. 2-Bromocyclopentanones react faster than 2- bromocyclohexanones than 2-bromocycloheptanones, but &#945;-chloro- and &#945;- iodo-cyclohexanones do not undergo alkylation. The stereochemistry of reagent and product is discussed and an efficient one-pot alkylation of cycloalkanones is described. 
ER  -

