
%0 Journal Article
%A Clark-Lewis, JW 
%A Cox, DP 
%T Flavonoid intermediates for the synthesis of mopanol trimethyl ether[<I>trans-trans</I>-7,7',8'-Trimethoxyisochromano(4',3':2,3)chroman-4-ol]
%J Australian Journal of Chemistry
%D 1976/01/01
%V 29
%N 1
%P 191-201
%K 
%R https://doi.org/10.1071/CH9760191
%U https://www.publish.csiro.au/paper/CH9760191 
%X Preparation of a number of intermediates for the synthesis of (±)-mopanol trimethyl ether is described, together with exploratory reactions with model compounds, and especially with 7-methoxyflavanone-2'-carboxylic acid. 7-Methoxyflavan-4-ol, the initial product from reduction of 7-methoxyflavanone-2'-carboxylic acid with complex metal hydrides, was found to undergo facile dehydration to a novel intramolecular dibenzyl ether [the cyclic ether (19)*]. It was noted that the methoxymethyl group, which may be used as a protecting group for phenols, did not survive the conditions of methylation with dimethyl sulphate and potassium carbonate in acetone. 
