
TY  - JOUR
A1  - Bhushan, K 
A1  - Lister, JH 
T1  - Purine studies. XVIII. The C- and N-alkylation of theophylline and derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1976
VL  - 29
IS  - 4
SP  - 891
EP  - 897
KW  - 
UR  - https://doi.org/10.1071/CH9760891 
N2  - Alkylation of theophylline in aqueous alkaline solution with benzyl halides gives, in addition to the expected N7 benzylated derivative, both 8-benzyl- and 7,8-dibenzyl-theophylline. Synthetic routes to these derivatives have been explored and unusual reactivity associated with benzyl groups in some of the intermediates has been demonstrated. Results which do not preclude the possibility that benzyl radicals could be responsible for the 8-benzylation reaction have been obtained. 
ER  -

