
%0 Journal Article
%A Hope, AP 
%A Halpern, B 
%T The application of ketimine derivatives of amino acids to peptide synthesis
%J Australian Journal of Chemistry
%D 1976/07/01
%V 29
%N 7
%P 1591-1603
%K 
%R https://doi.org/10.1071/CH9761591
%U https://www.publish.csiro.au/paper/CH9761591 
%X N-(2-Hydroxyarylmethy1ene)amino acids have been coupled with amino acid esters to form sterically pure N-protected dipeptide esters. The protecting group can be removed by means of 80% acetic acid under conditions which leaves the t-butyloxycarbonyl protecting group intact. Biologically active peptides which are C-terminal partial sequences of substance P were prepared and were shown to have the expected vasodilator, spasmogenic and venoconstrictor properties. 
