
%0 Journal Article
%A Deady, LW 
%A Stillman, DC 
%T Steric effects in quaternizations. Alkylation of pyridine, thiazole, isothiazole and some benzologues with methyl, ethyl and isopropyl iodides
%J Australian Journal of Chemistry
%D 1976/08/01
%V 29
%N 8
%P 1745-1748
%K 
%R https://doi.org/10.1071/CH9761745
%U https://www.publish.csiro.au/paper/CH9761745 
%X Results of quaternization reactions in sulpholane at 65º are reported. A large steric hindrance is noted for quinoline relative to pyridine. A much smaller variation in rate with change in alkyl halide is seen in the benzothiazole/thiazole pair. Steric effects are very small and the rate retardation resulting from benzofusion is ascribed largely to an electronic effect. 2,l-Benzisothiazole reacts at essentially the same rate as isothiazole under these conditions. 
