
%0 Journal Article
%A Calder, IC 
%A Creek, MJ 
%T Reactions of N-acetoxyphenacetin: an <I>in vitro</I> model for the metabolism of phenacetin
%J Australian Journal of Chemistry
%D 1976/08/01
%V 29
%N 8
%P 1801-1808
%K 
%R https://doi.org/10.1071/CH9761801
%U https://www.publish.csiro.au/paper/CH9761801 
%X The solvolysis reactions of N-acetoxy-4'-ethoxyacetanilide in the presence of nucleophiles under neutral conditions and at low pH yield p-benzoquinone, 3'-substituted 4'-hydroxyacetanilides and 2'-substituted 4'-ethoxyacetanilides. The product ratio is dependent on the nature of the nucleophile and the pH. This type of reaction accounts for many of the minor metabolites of phenacetin. 
