
%0 Journal Article
%A Richards, CM 
%A Hofmann, A 
%T Pyridone analogues of tetrahydroisoquinolines and protoberberines from mimosine and mimosinamine
%J Australian Journal of Chemistry
%D 1978/01/01
%V 31
%N 1
%P 187-191
%K 
%R https://doi.org/10.1071/CH9780187
%U https://www.publish.csiro.au/paper/CH9780187 
%X Several pyrido[1,2-a]piperazines and their N-methyl derivatives have been prepared. These pyridine analogues of the 1,2,3,4-tetrahydroisoquinolines were formed by condensation of carbonyl compounds with mimosine and mimosinamine in the absence of an acid catalyst. A Mannich reaction converted one of these compounds, 1-(3,4-dimethoxybenzyl)-9-hydroxy-1,2,3,4-tetrahydro-8H-pyrido[1,2-a]- pyrazin-8-one, into a pyridone analogue of the tetrahydroprotoberberine caseadine. 
