
%0 Journal Article
%A Brown, DJ 
%A Dunlap, WC 
%A Grigg, GW 
%A Danckwerts, L 
%T Purine analogues as amplifiers of phleomycin. III. Some 2-alkylthio derivatives of imidazole, benzimidazole, benzoxazole and benzothiazole
%J Australian Journal of Chemistry
%D 1978/02/01
%V 31
%N 2
%P 447-450
%K 
%R https://doi.org/10.1071/CH9780447
%U https://www.publish.csiro.au/paper/CH9780447 
%X Some 2-methylthio and 2-carbamoylalkylthio derivatives of 1-methylimidazole, benzimidazole, benzoxazole, benzothiazole and 6-dimethylaminobenzothiazole have been synthesized by alkylation of the corresponding thiones. Their in vitro activities, as amplifiers of phleomycin against Escherichia coli, varied from slight to high but none was outstanding. 2-(Benzothiazol-2'-ylthio)acetamide (2j)showed maximal activity at c. 0.04 mM with progressive decreases at both higher and lower concentrations. 
